University of Wisconsin – Madison

Brian Strahl, Ph.D.

Dr. Shanle is currently Assistant Professor in the Department of Biology at Longwood University in Farmville, VA.

• Fall 2015
  • Principles of Biology w/lab, Department of Biology, UNC Pembroke
• Spring 2015
  • Molecular Biology, with lab, Department of Biology, UNC Pembroke

• Slaughter MJ- Shanle EK- Khan A- Chua KF- Hong T- Boxer LD- Allis CD- Josefowicz SZ- Garcia BA- Rothbart SB- Strahl BD- Davis IJ. HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.. Cell reports. 2021 Jan 19;34(3):108638. 10.1016/j.celrep.2020.108638. 33472068. pmc-id: PMC7886050

• Slaughter MJ, Shanle EK, McFadden AW, Hollis ES, Suttle LE, Strahl BD, Davis IJ. Polybromo-1 (PBRM1) bromodomains variably influence nucleosome interactions and cellular function.. The Journal of biological chemistry. 2018
• Shanle EK– Shinsky SA- Bridgers JB- Bae N- Sagum C- Krajewski K- Rothbart SB- Bedford MT- Strahl BD. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.. Epigenetics & chromatin. 2017;10:12
• Savitsky P- Krojer T- Fujisawa T- Lambert JP- Picaud S- Wang CY- Shanle EK– Krajewski K- Friedrichsen H- Kanapin A- Goding C- Schapira M- Samsonova A- Strahl BD- Gingras AC- Filippakopoulos P. Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.. Cell reports. 2016 Dec 6;17(10):2724-2737
• Andrews FH- Shanle EK– Strahl BD- Kutateladze TG. The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation.. Transcription. 2016 Jan;7(1):14-20. 10.1080/21541264.2015.1125987. 26934307. pmc-id: PMC4802754
• Shanle EK– Tsun IK- Strahl BD. A course-based undergraduate research experience investigating p300 bromodomain mutations.. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. 2016 Jan 2;44(1):68-74.
• Shanle EK– Andrews FH- Meriesh H- McDaniel SL- Dronamraju R- DiFiore JV- Jha D- Wozniak GG- Bridgers JB- Kerschner JL- Krajewski K- Martín GM- Morrison AJ- Kutateladze TG- Strahl BD. Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.. Genes & development. 2015 Sep 1;29(17):1795-800. pmc-id: PMC4573853
• Rothbart SB- Dickson BM- Raab JR- Grzybowski AT- Krajewski K- Guo AH- Shanle EK– Josefowicz SZ- Fuchs SM- Allis CD- Magnuson TR- Ruthenburg AJ- Strahl BD. An Interactive Database for the Assessment of Histone Antibody Specificity.. Molecular cell. 2015 Aug 6;59(3):502-11. 26212453. pmc-id: PMC4530063
• Dumesic PA- Homer CM- Moresco JJ- Pack LR- Shanle EK– Coyle SM- Strahl BD- Fujimori DG- Yates JR 3rd- Madhani HD. Product binding enforces the genomic specificity of a yeast polycomb repressive complex.. Cell. 2015 Jan 15;160(1-2):204-18. 10.1016/j.cell.2014.11.039. 25533783. pmc-id: PMC4303595
• Shanle EK, Rothbart SB, Strahl BD. (2014) Chromatin biochemistry enters the next generation of code ‘seq-ing’. Nat Methods. Aug;11(8):799-800.