Tori Hoskins, Ph.D.
Biochemistry & Biophysics
Johns Hopkins School of Medicine – Human Genetics
Brian Strahl, Ph.D.
My science education began early at the NC School of Science and Mathematics where I was first introduced to the world of scientific research and had the opportunity to learn from fantastic teachers from different disciplines. I continued into undergraduate at Wake Forest University where I got my B.S. in Biology. While there, I worked in several research labs, most notably, the lab of Dr. Ke Zhang, which sparked my interest in epigenetics and ultimately led me to pursue my Ph.D. in Human Genetics at the Johns Hopkins School of Medicine.
While at Johns Hopkins I studied 3D genome organization in the labs of Dr. Karen Reddy and Dr. Loyal Goff. I wanted to understand how the repressive compartment of the genome becomes re-established at the nuclear periphery after cell division. I discovered that compartmentalization begins as early as anaphase when the repressive compartment of each chromosome aggregates together prior to nuclear lamina formation. However, these repressive aggregates do not become anchored at the nuclear periphery until well into G1 phase. I further found that lamin C plays a crucial role in the aggregation of heterochromatin and its establishment at the nuclear periphery. While at Johns Hopkins I also explored my interests in science education and participated in the JHU Teaching Academy and the Collaborative Teaching Fellowship. Through these programs I was able to form a foundation in pedagogical strategies and apply some of these skills while teaching at Goucher College and Loyola University Maryland.
Through the SPIRE program I am excited to continue both my research and pedagogical training. I will be conducting my post-doctoral research in the lab of Dr. Brian Strahl exploring the role of the histone post-translation modification crotylation and one of its possible readers, sas5, with regards to heterochromatin boundaries and chromatin integrity. I am eager to see where this research will lead me and to get back into the classroom!