Kelsey Kean, Ph.D.
Chemistry
Education
Oregon State University
Mentors
Marcey Waters, Ph.D.
Biography
Dr. Kean is currently Assistant Professor of Chemistry at High Point University in High Point, NC
Courses
Fall 2020 Biological Chemistry – North Carolina Central University
Spring 2020 Principles of Biology: Molecules and Cells – North Carolina Central University
Publications
Travis CR-Albanese KI-Henriksen HC-Kean KM-Waters ML. Evaluation of Cooperative Binding of Histone Post-Translational Modifications and the Surrounding Sequence by Trimethyllysine Reader Proteins.. Biochemistry. 2025 Nov 4;64(21):4367-4373. PMID: 41100741. . PMCID: NIHMS2127275.
Travis CR, Kean KM, Albanese KI, Henriksen HC, Treacy JW, Chao EY, Houk KN, Waters ML. Trimethyllysine Reader Proteins Exhibit Widespread Charge-Agnostic Binding via Different Mechanisms to Cationic and Neutral Ligands. J Am Chem Soc. 2024 Feb 7;146(5):3086-3093. doi: 10.1021/jacs.3c10031. Epub 2024 Jan 24. PMID: 38266163; PMCID: PMC11140585.
Stingley KJ- Carpenter BA- Kean KM– Waters ML. Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles. Chemical science. 2023 May 10;14(18):4935-4944. PMCID: PMC10171189.
Kean KM, Baril SA, Lamb KN, Dishman SN, Treacy JW, Houk KN, Brustad EM, James LI, Waters ML. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. Journal of medicinal chemistry. 2022 February 10;65(3):2646-2655. PubMed PMID: 35014255; PubMed Central PMCID: PMC9048841; DOI: 10.1021/acs.jmedchem.1c02049.